Term id	GO:0003924
Term name	GTPase activity
Term definition	Catalysis of the reaction: GTP + H2O = GDP + phosphate.
Comment

Synoyms
ARF small monomeric GTPase activity NARROW
dynamin GTPase activity NARROW
heterotrimeric G-protein GTPase activity NARROW
heterotrimeric G-protein GTPase, alpha-subunit RELATED
heterotrimeric G-protein GTPase, beta-subunit RELATED
heterotrimeric G-protein GTPase, gamma-subunit RELATED
hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement BROAD
protein-synthesizing GTPase activity NARROW
protein-synthesizing GTPase activity, elongation NARROW
protein-synthesizing GTPase activity, initiation NARROW
protein-synthesizing GTPase activity, termination NARROW
Rab small monomeric GTPase activity NARROW
Ran small monomeric GTPase activity NARROW
Ras small monomeric GTPase activity NARROW
RHEB small monomeric GTPase activity NARROW
Rho small monomeric GTPase activity NARROW
Sar small monomeric GTPase activity NARROW
signal-recognition-particle GTPase activity NARROW
small monomeric GTPase activity NARROW
tubulin GTPase activity NARROW
"ARF small monomeric GTPase activity" NARROW []
"dynamin GTPase activity" NARROW []
"heterotrimeric G-protein GTPase activity" NARROW []
"heterotrimeric G-protein GTPase, alpha-subunit" RELATED []
"heterotrimeric G-protein GTPase, beta-subunit" RELATED []
"heterotrimeric G-protein GTPase, gamma-subunit" RELATED []
"hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD []
"protein-synthesizing GTPase activity" NARROW []
"protein-synthesizing GTPase activity, elongation" NARROW []
"protein-synthesizing GTPase activity, initiation" NARROW []
"protein-synthesizing GTPase activity, termination" NARROW []
"Rab small monomeric GTPase activity" NARROW []
"Ran small monomeric GTPase activity" NARROW []
"Ras small monomeric GTPase activity" NARROW []
"RHEB small monomeric GTPase activity" NARROW []
"Rho small monomeric GTPase activity" NARROW []
"Sar small monomeric GTPase activity" NARROW []
"signal-recognition-particle GTPase activity" NARROW []
"small monomeric GTPase activity" NARROW []
"tubulin GTPase activity" NARROW []

Definition dbxrefs

Related dbxrefs
Reactome:REACT_100432 "trans-Golgi Network Vesicle Scission, Mus musculus"
Reactome:REACT_100708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Bos taurus"
Reactome:REACT_101121 "trans-Golgi Network Vesicle Scission, Rattus norvegicus"
Reactome:REACT_101520 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster"
Reactome:REACT_101563 "Loss of Sar1b GTPase, Arabidopsis thaliana"
Reactome:REACT_101678 "G-protein alpha subunit is inactivated, Gallus gallus"
Reactome:REACT_102040 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis"
Reactome:REACT_102208 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Danio rerio"
Reactome:REACT_102307 "Adenylate cyclase increases the GTPase activity of Gi alpha, Gallus gallus"
Reactome:REACT_102371 "Vesicle Uncoating, Oryza sativa"
Reactome:REACT_102510 "trans-Golgi Network Vesicle Scission, Bos taurus"
Reactome:REACT_102532 "Loss of Sar1b GTPase, Danio rerio"
Reactome:REACT_103518 "trans-Golgi Network Lysosomal Vesicle Scission, Sus scrofa"
Reactome:REACT_104081 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
Reactome:REACT_104477 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
Reactome:REACT_104739 "Loss of Sar1b GTPase, Dictyostelium discoideum"
Reactome:REACT_105323 "trans-Golgi Network Vesicle Scission, Canis familiaris"
Reactome:REACT_105697 "G-protein alpha subunit is inactivated, Saccharomyces cerevisiae"
Reactome:REACT_105708 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
Reactome:REACT_105854 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
Reactome:REACT_106121 "Vesicle Uncoating, Saccharomyces cerevisiae"
Reactome:REACT_106217 "Hydrolysis of eEF1A
Reactome:REACT_106301 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Mus musculus"
Reactome:REACT_106528 "trans-Golgi Network Lysosomal Vesicle Scission, Canis familiaris"
Reactome:REACT_107176 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
Reactome:REACT_107306 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus"
Reactome:REACT_107730 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae"
Reactome:REACT_107820 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Canis familiaris"
Reactome:REACT_108363 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster"
Reactome:REACT_108653 "G-protein alpha subunit is inactivated, Bos taurus"
Reactome:REACT_108825 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Drosophila melanogaster"
Reactome:REACT_108837 "trans-Golgi Network Vesicle Scission, Xenopus tropicalis"
Reactome:REACT_109360 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
Reactome:REACT_109897 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Danio rerio"
Reactome:REACT_110131 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
Reactome:REACT_110443 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
Reactome:REACT_110557 "trans-Golgi Network Vesicle Scission, Danio rerio"
Reactome:REACT_110859 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans"
Reactome:REACT_110879 "G-protein alpha subunit is inactivated, Canis familiaris"
Reactome:REACT_110931 "G-protein alpha subunit is inactivated, Sus scrofa"
Reactome:REACT_111994 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
Reactome:REACT_112104 "Endocytosis (internalization) of clathrin-coated vesicle, Sus scrofa"
Reactome:REACT_112254 "Endocytosis (internalization) of clathrin-coated vesicle, Xenopus tropicalis"
Reactome:REACT_112389 "Disassembly of COPII coated vesicle, Gallus gallus"
Reactome:REACT_112587 "trans-Golgi Network Vesicle Scission, Schizosaccharomyces pombe"
Reactome:REACT_112651 "Vesicle Uncoating, Xenopus tropicalis"
Reactome:REACT_112671 "Vesicle Uncoating, Plasmodium falciparum"
Reactome:REACT_113058 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae"
Reactome:REACT_113209 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe"
Reactome:REACT_113727 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Saccharomyces cerevisiae"
Reactome:REACT_113832 "Formation of clathrin coated vesicle, Bos taurus"
Reactome:REACT_113952 "Formation of clathrin coated vesicle, Schizosaccharomyces pombe"
Reactome:REACT_113954 "Endocytosis (internalization) of clathrin-coated vesicle, Schizosaccharomyces pombe"
Reactome:REACT_114148 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe"
Reactome:REACT_114153 "Loss of Sar1b GTPase, Xenopus tropicalis"
Reactome:REACT_114188 "Formation of clathrin coated vesicle, Sus scrofa"
Reactome:REACT_114210 "G-protein alpha subunit is inactivated, Schizosaccharomyces pombe"
Reactome:REACT_114331 "trans-Golgi Network Vesicle Scission, Taeniopygia guttata"
Reactome:REACT_114379 "Formation of clathrin coated vesicle, Taeniopygia guttata"
Reactome:REACT_114384 "Hydrolysis of eEF1A
Reactome:REACT_114532 "Formation of clathrin coated vesicle, Xenopus tropicalis"
Reactome:REACT_114620 "Endocytosis (internalization) of clathrin-coated vesicle, Taeniopygia guttata"
Reactome:REACT_114824 "trans-Golgi Network Lysosomal Vesicle Scission, Taeniopygia guttata"
Reactome:REACT_115229 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Schizosaccharomyces pombe"
Reactome:REACT_115324 "Endocytosis (internalization) of clathrin-coated vesicle, Bos taurus"
Reactome:REACT_12396 "Loss of Sar1b GTPase, Homo sapiens"
Reactome:REACT_12397 "Endocytosis (internalization) of clathrin-coated vesicle, Homo sapiens"
Reactome:REACT_12456 "Vesicle Uncoating, Homo sapiens"
Reactome:REACT_12612 "Endocytosis of clathrin-coated vesicle, Rattus norvegicus"
Reactome:REACT_15316 "G-protein alpha subunit is inactivated, Homo sapiens"
Reactome:REACT_15335 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Homo sapiens"
Reactome:REACT_15449 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Homo sapiens"
Reactome:REACT_15495 "Adenylate cyclase increases the GTPase activity of Gi alpha, Homo sapiens"
Reactome:REACT_19123 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
Reactome:REACT_19178 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
Reactome:REACT_19186 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
Reactome:REACT_19194 "trans-Golgi Network Lysosomal Vesicle Scission, Homo sapiens"
Reactome:REACT_19219 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
Reactome:REACT_19255 "trans-Golgi Network Vesicle Scission, Homo sapiens"
Reactome:REACT_19317 "G alpha (i)1 auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus"
Reactome:REACT_22359 "Formation of clathrin coated vesicle, Homo sapiens"
Reactome:REACT_28065 "Vesicle Uncoating, Sus scrofa"
Reactome:REACT_28251 "Hydrolysis of eEF1A
Reactome:REACT_28269 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Gallus gallus"
Reactome:REACT_29162 "trans-Golgi Network Lysosomal Vesicle Scission, Mus musculus"
Reactome:REACT_30456 "Hydrolysis of eEF1A
Reactome:REACT_30463 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Bos taurus"
Reactome:REACT_30562 "Endocytosis (internalization) of clathrin-coated vesicle, Caenorhabditis elegans"
Reactome:REACT_30687 "G-protein alpha subunit is inactivated, Xenopus tropicalis"
Reactome:REACT_30707 "trans-Golgi Network Vesicle Scission, Caenorhabditis elegans"
Reactome:REACT_30942 "Vesicle Uncoating, Rattus norvegicus"
Reactome:REACT_31226 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
Reactome:REACT_31474 "Formation of clathrin coated vesicle, Danio rerio"
Reactome:REACT_31530 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Caenorhabditis elegans"
Reactome:REACT_31599 "trans-Golgi Network Lysosomal Vesicle Scission, Danio rerio"
Reactome:REACT_31709 "Hydrolysis of eEF1A
Reactome:REACT_31727 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata"
Reactome:REACT_31850 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
Reactome:REACT_32006 "Loss of Sar1b GTPase, Canis familiaris"
Reactome:REACT_32028 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Danio rerio"
Reactome:REACT_32914 "Vesicle Uncoating, Dictyostelium discoideum"
Reactome:REACT_33948 "trans-Golgi Network Lysosomal Vesicle Scission, Rattus norvegicus"
Reactome:REACT_34113 "Vesicle Uncoating, Schizosaccharomyces pombe"
Reactome:REACT_34480 "G-protein alpha subunit is inactivated, Caenorhabditis elegans"
Reactome:REACT_34592 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
Reactome:REACT_34735 "Adenylate cyclase increases the GTPase activity of Gi alpha, Taeniopygia guttata"
Reactome:REACT_348 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Homo sapiens"
Reactome:REACT_36834 "trans-Golgi Network Lysosomal Vesicle Scission, Bos taurus"
Reactome:REACT_37542 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
Reactome:REACT_552 "Hydrolysis of eEF1A
Reactome:REACT_6171 "Hydrolysis of Ran
Reactome:REACT_712 "Hydrolysis of reEF1A
Reactome:REACT_75799 "Disassembly of COPII coated vesicle, Homo sapiens"
Reactome:REACT_77032 "Hydrolysis of eEF1A
Reactome:REACT_77303 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Danio rerio"
Reactome:REACT_78069 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans"
Reactome:REACT_78231 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
Reactome:REACT_78653 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Bos taurus"
Reactome:REACT_78945 "G-protein alpha subunit is inactivated, Rattus norvegicus"
Reactome:REACT_79558 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
Reactome:REACT_79620 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Mus musculus"
Reactome:REACT_80275 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Bos taurus"
Reactome:REACT_80612 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
Reactome:REACT_81304 "Loss of Sar1b GTPase, Taeniopygia guttata"
Reactome:REACT_81448 "Endocytosis (internalization) of clathrin-coated vesicle, Canis familiaris"
Reactome:REACT_81580 "Disassembly of COPII coated vesicle, Mus musculus"
Reactome:REACT_81664 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Caenorhabditis elegans"
Reactome:REACT_81879 "Vesicle Uncoating, Drosophila melanogaster"
Reactome:REACT_82203 "Formation of clathrin coated vesicle, Canis familiaris"
Reactome:REACT_82263 "G-protein alpha subunit is inactivated, Taeniopygia guttata"
Reactome:REACT_82457 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Taeniopygia guttata"
Reactome:REACT_82603 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
Reactome:REACT_82704 "Loss of Sar1b GTPase, Rattus norvegicus"
Reactome:REACT_83308 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus"
Reactome:REACT_83403 "G-protein alpha subunit is inactivated, Drosophila melanogaster"
Reactome:REACT_83440 "Hydrolysis of eEF1A
Reactome:REACT_83730 "Loss of Sar1b GTPase, Plasmodium falciparum"
Reactome:REACT_84204 "Endocytosis (internalization) of clathrin-coated vesicle, Danio rerio"
Reactome:REACT_84553 "Vesicle Uncoating, Canis familiaris"
Reactome:REACT_84696 "G-protein alpha subunit is inactivated, Danio rerio"
Reactome:REACT_84712 "Hydrolysis of eEF1A
Reactome:REACT_84735 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Rattus norvegicus"
Reactome:REACT_85008 "Vesicle Uncoating, Danio rerio"
Reactome:REACT_85418 "Loss of Sar1b GTPase, Gallus gallus"
Reactome:REACT_85769 "Disassembly of COPII coated vesicle, Danio rerio"
Reactome:REACT_85972 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Canis familiaris"
Reactome:REACT_86227 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum"
Reactome:REACT_86358 "trans-Golgi Network Lysosomal Vesicle Scission, Caenorhabditis elegans"
Reactome:REACT_86400 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum"
Reactome:REACT_86630 "Vesicle Uncoating, Mus musculus"
Reactome:REACT_86760 "Adenylate cyclase increases the GTPase activity of G alpha-olf, Gallus gallus"
Reactome:REACT_86972 "Loss of Sar1b GTPase, Mus musculus"
Reactome:REACT_87409 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum"
Reactome:REACT_87506 "Formation of clathrin coated vesicle, Rattus norvegicus"
Reactome:REACT_87558 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
Reactome:REACT_87653 "Endocytosis (internalization) of clathrin-coated vesicle, Mus musculus"
Reactome:REACT_87661 "Formation of clathrin coated vesicle, Drosophila melanogaster"
Reactome:REACT_88045 "Vesicle Uncoating, Gallus gallus"
Reactome:REACT_88357 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
Reactome:REACT_89231 "Loss of Sar1b GTPase, Bos taurus"
Reactome:REACT_89292 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
Reactome:REACT_89416 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Bos taurus"
Reactome:REACT_89668 "trans-Golgi Network Lysosomal Vesicle Scission, Xenopus tropicalis"
Reactome:REACT_89763 "Vesicle Uncoating, Taeniopygia guttata"
Reactome:REACT_90050 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
Reactome:REACT_90064 "Hydrolysis of eEF1A
Reactome:REACT_90517 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Xenopus tropicalis"
Reactome:REACT_90703 "G-protein alpha subunit is inactivated, Dictyostelium discoideum"
Reactome:REACT_91199 "Adenylate cyclase increases the GTPase activity of Gi alpha, Bos taurus"
Reactome:REACT_91588 "trans-Golgi Network Vesicle Scission, Drosophila melanogaster"
Reactome:REACT_92176 "Endocytosis (internalization) of clathrin-coated vesicle, Drosophila melanogaster"
Reactome:REACT_92197 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Bos taurus"
Reactome:REACT_92198 "Loss of Sar1b GTPase, Oryza sativa"
Reactome:REACT_92450 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Danio rerio"
Reactome:REACT_93249 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Dictyostelium discoideum"
Reactome:REACT_93305 "Loss of Sar1b GTPase, Sus scrofa"
Reactome:REACT_93641 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
Reactome:REACT_93742 "G-protein alpha subunit is inactivated, Mus musculus"
Reactome:REACT_93772 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Gallus gallus"
Reactome:REACT_94019 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
Reactome:REACT_94095 "trans-Golgi Network Vesicle Scission, Sus scrofa"
Reactome:REACT_94305 "Adenylate cyclase increases the GTPase activity of Gi alpha, Xenopus tropicalis"
Reactome:REACT_94760 "Adenylate cyclase increases the GTPase activity of Gi alpha, Danio rerio"
Reactome:REACT_95238 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Rattus norvegicus"
Reactome:REACT_95563 "Adenylate cyclase increases the GTPase activity of Gi alpha, Canis familiaris"
Reactome:REACT_96019 "Loss of Sar1b GTPase, Drosophila melanogaster"
Reactome:REACT_96132 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Drosophila melanogaster"
Reactome:REACT_96223 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
Reactome:REACT_96612 "Adenylate cyclase increases the GTPase activity of Gi alpha, Rattus norvegicus"
Reactome:REACT_96881 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Xenopus tropicalis"
Reactome:REACT_97284 "Loss of Sar1b GTPase, Saccharomyces cerevisiae"
Reactome:REACT_97405 "Adenylaye cyclase increases the GTPase activity of G alpha-olf, Taeniopygia guttata"
Reactome:REACT_97595 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Danio rerio"
Reactome:REACT_97794 "Loss of Sar1b GTPase, Schizosaccharomyces pombe"
Reactome:REACT_98431 "Formation of clathrin coated vesicle, Caenorhabditis elegans"
Reactome:REACT_98556 "Vesicle Uncoating, Bos taurus"
Reactome:REACT_98837 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP, Canis familiaris"
Reactome:REACT_98859 "Adenylate cyclase increases the GTPase activity of Gi alpha, Mus musculus"
Reactome:REACT_99479 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP, Mus musculus"
Reactome:REACT_99533 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP, Sus scrofa"
Reactome:REACT_99616 "Formation of clathrin coated vesicle, Mus musculus"
RHEA:19672

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