GO:0008398 'sterol 14-demethylase activity'
| Cvterm details |
| Term id | GO:0008398 |
| Term name | sterol 14-demethylase activity |
| Term definition | Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O. |
| Comment |
Synoyms
cytochrome P450 51 activity NARROW EC:1.14.13.70
cytochrome P450 CYP51 NARROW
lanosterol 14-alpha-demethylase activity NARROW EC:1.14.13.70
lanosterol 14-demethylase activity NARROW EC:1.14.13.70
lanosterol 14alpha-demethylase activity EXACT EC:1.14.13.70
obtusufoliol 14-demethylase activity NARROW EC:1.14.13.70
sterol 14-alpha-demethylase activity EXACT EC:1.14.13.70
sterol 14alpha-demethylase activity EXACT EC:1.14.13.70
sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving) EXACT EC:1.14.13.70
"cytochrome P450 51 activity" NARROW [EC:1.14.13.70]
"cytochrome P450 CYP51" NARROW []
"lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70]
"lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70]
"lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70]
"obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70]
"sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70]
"sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70]
"sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70]
Definition dbxrefs
Related dbxrefs
MetaCyc:1.14.13.70-RXN
Reactome:REACT_10006 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Homo sapiens"
Reactome:REACT_29216 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Sus scrofa"
Reactome:REACT_32427 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Danio rerio"
Reactome:REACT_32453 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Taeniopygia guttata"
Reactome:REACT_78438 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Xenopus tropicalis"
Reactome:REACT_79266 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Saccharomyces cerevisiae"
Reactome:REACT_80783 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Oryza sativa"
Reactome:REACT_87749 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Mycobacterium tuberculosis"
Reactome:REACT_92607 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Mus musculus"
Reactome:REACT_93847 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Schizosaccharomyces pombe"
Reactome:REACT_93854 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Gallus gallus"
Reactome:REACT_95701 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Bos taurus"
Reactome:REACT_96210 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Canis familiaris"
Reactome:REACT_98680 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Dictyostelium discoideum"
Reactome:REACT_99457 "Lanosterol is oxidatively demethylated to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol, Arabidopsis thaliana"
RHEA:14920
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